James Milner, Alex Oxlade-Chamberlain, and Naby Keita, with a combined total of 607 appearances, have already departed as their contracts expired.
Surprisingly, Jordan Henderson, who has made 491 appearances for the club, and Fabinho, with 219 appearances, also appear to be heading towards an exit.
This signifies that manager Jurgen Klopp’s plan for a midfield renovation has now transformed into a comprehensive rebuild.
Brazilian international Fabinho received a £40m bid from Saudi Arabian club Al-Ittihad, resulting in his absence from the Reds squad’s training camp in Germany.
Henderson, on the other hand, traveled despite links with Al-Ettifaq.
However, after being left out of Liverpool’s first pre-season game against Karlsruher, it emerged that the club had agreed to sell him to the Saudi side for £12m plus add-ons.
Both Henderson and Fabinho had a challenging season but showed signs of improvement as the team won seven out of their final nine games.
Unlike Milner, Oxlade-Chamberlain, and Keita, they were not expected to leave Anfield.
The initial plan was to supplement the signings of attacking midfielders Alexis Mac Allister and Dominik Szoboszlai with a long-term successor to 29-year-old Fabinho.
Southampton’s 19-year-old Romeo Lavia was considered for this role, but Fabinho’s impending departure has altered the landscape.
Replacing Fabinho is a more complex task compared to accommodating Henderson’s potential departure, as the current midfielders at the club can absorb his absence.
While 18-year-old Stefan Bajcetic impressed under Klopp last season, the responsibility of filling Fabinho’s role may be too much for him, especially considering his ongoing recovery from a thigh injury since March.
Curtis Jones and Harvey Elliott will return after their involvement in England’s successful European Under-21 Championship campaign, but along with Thiago Alcantara, they are not specialized holding midfielders.
Brighton’s Moises Caicedo would be a suitable option, but he is expected to join Chelsea, although the Blues have yet to reach an agreement for the 21-year-old despite a £70m bid being rejected.