Osimertinib, sold under the brand name Tagrisso, is available to patients with Stage 1B-3A lung cancer who have a certain genetic mutation and have had surgery to remove cancerous tumors.
Among those patients, Tagrisso was shown to reduce the five-year risk of recurrent cancer by up to 73% and the risk of death by up to 51%, according to research published in The New England Journal of Medicine over the summer.
“In the world of oncology, that is earth-shattering,” Dr. Faiz Y. Bhora, chief of thoracic surgery and central region chair of surgery at Hackensack Meridian Health in New Jersey, said.
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“In the past, medical oncologists were happy with 5% or 10% — and now we’re talking about in excess of 50% improvement in survival.”
Bhora, who has prescribed the medication to several of his lung cancer patients, spoke about the “groundbreaking” results he’s seen in his own practice.
“We’re truly in the era of personalized medicine. We now have a lot of targeted therapies that work well for patients who have mutations in their tumors,” Bhora said.
For this particular medication, patients who have a genetic mutation called EGFRm — and who have already had surgery — are viable candidates for Tagrisso.
“The pill helps prevent recurrence once the tumor is removed with surgery for those with the genetic marker,” he said.
Patients with stage 4 lung cancer are also eligible for the pill if they have the EGFR mutation, even without having had surgery, the doctor noted.
To determine if a patient has the mutation, a tissue sample is extracted from the tumor and tested. Results are typically obtained within 10 to 14 days.
A blood test is also available, Bhora said, with those results available within five to 21 days. “We used to think of lung cancer as just a smoker’s illness. Now, we know that over 30% of individuals who develop lung cancer have never smoked,” he said.
“We used to think of lung cancer as just a smoker’s illness. Now, we know that over 30% of individuals who develop lung cancer have never smoked.”
“We used to think of lung cancer as just a smoker’s illness,” Bhora said. “Now, we know that over 30% of individuals who develop lung cancer have never smoked, and a lot of them are women.”
Looking ahead, he hopes to be able to prescribe the pill soon to patients upfront, before any other procedures or therapies, with the goal of shrinking tumors prior to surgery.
Kim Mosko, 67, was diagnosed with stage 2A lung cancer in February 2023. The mother of two had robotic surgery at Hackensack Meridian just a couple of weeks later.
“The lobectomy was performed by robotic surgery and was an incredible experience. I owe all the doctors I see and consulted with a debt I can never repay,” she said.
Next, she had four rounds of chemotherapy, which she completed at the end of June 2023.
“I absolutely believe that this medication is going to make sure the lung cancer will not return. I am planning on living for many more years.”
When Mosko’s doctors determined in July that she has the genetic mutation, they recommended that she take Tagrisso. “I needed no persuasion at all,” she told Fox News Digital. “I will do whatever is necessary to treat this cancer and lengthen my lifespan.”
Mosko has now been taking Tagrisso for 3½ months, with plans to continue taking it daily for three years. Her insurance covers the cost of the medication.
“Overall, my experience has been positive, and I am grateful that this medication is available,” she said.
She has experienced some side effects, such as a skin rash, diarrhea and fatigue, “all of which are manageable,” Mosko said.
“I don’t need to have hope,” she added. “I absolutely believe that this medication is going to make sure the lung cancer will not return. I am planning on living for many more years.”
For lung cancer patients interested in Tagrisso, Bhora recommends seeing an experienced team of physicians to get tested for the genetic mutation. At Hackensack, Bhora said, “we consider every patient a candidate for a cure.”
With the advent of personalized therapies, he believes there is hope on the horizon for many lung cancer patients.
“This is a very optimistic time for patients who used to have what was universally considered a fatal disease,” Bhora said.
“We are now in an era where in a vast majority of cases, we can either turn it into a chronic disease or aim for a complete cure.”
First published on Fox News.
